That is quite unfortunate. I will not bother playing/installing games that are incompatible with the itchio desktop application.
If you'd like to consider making the exe file compatible, please consider reading this developer guide on how to begin the process and expand your audience a bit more.
Best of luck to the devs for all the work they do. Cheers!
EDIT: I was able to get that 'SomeStreet.zip' HTML5 file to install/run in the desktop application. Might want to put a note on the main game page for those using the itchio desktop application that they should install that file instead of the exe one.