I really liked the way the dice looked. I also loved how upgrading the dice changed the number of faces (d4 to a d6).
I did find that most of the time the yellow dice felt like it wasn't doing anything. The difficulty ramped up quite fast too - I was unable to one of the enemies as it has way too much health and I was only doing 1 damage. My run was ended when I accidently rolled no dice too.
Apart from some minor balance issues, this is a really good concept. The problems stem from the random nature of the gameplay but since that was the theme, it's okay that its like that.
Great job!