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Tiled is a standalone program. It is used to create map files that can then be used in your game engine to load up maps. I wouldn't necessarily say that it is compatible with "all" game making programs but a lot of engines have Tiled support out of the box. Programmers can write a Tiled Loader in their favorite programming language.

Thank you. Actually a couple of minutes ago I figured out that my game maker engine has a tiled based system that I have no idea how to use. I might use this program now :D.