I've been practicing runs where I can only use my mouse for upgrades however I'm not sure what to call it, aimless, mouseless, pacifist or shotless.
Also on the run after I bought all the upgrades I got to 2:XX left and everything went red making it really hard to see anything, after I died it was still red so I refreshed the page progress was lost but it stopped being red.
Edit: the run where I got to under 3mins wasn't an aimless, mouseless, pacifist or shotless run.