Update: sometimes the game doesn't work, even after being installed in the Downloads folder; when that happens, I look for the Save folder, check Properties, and uncheck the Read Only box (it appears with a blue square filling the box); seems to work so far.
the game will require its folders to be writeable for it to run and autosave to function, so that tracks. I do recommend moving the game folder to elsewhere other than the Downloads folder just to be sure.