After some testing, it seems to be an issue with the YouTube mod. the game runs fine without it though.
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Does it happen right away after entering text, when you move (and the first doors open), or on a delay? This might help determine where the crash is, but in general that module is a little hairy because it runs youtube-dl.exe in the background to collect video data.
I also have some playback issues where videos from YouTube like to stall when playing or never load if they're too long. I can resolve the length issue by adding a length filter, but the stalling is strange. Crashes though, those need to be fixed with the highest priority.
I still haven't figured this one out. I did have a rare issue where the game would freeze while the YouTube scanner was working and indicate it was "not responding", but it would unfreeze itself after a short time. I tried to inspect what the game was doing while frozen but have not yet been able to find the problem. I did make some changes in this latest version to the YouTube scanner that might help or might not change anything with this bug. The bug is very rare for me but you seem to get it a lot.
Because the mod manager is so crude and simple to actually see the changes you'll need to click the "Remove Mod Loader and Mods" button to remove the old mod loader and mods and then click "Install Mod Loader" to copy the new loader in. This is how every update will be until I come up with a way for the mod manager to know if an old loader/mod is installed.