Your wife is a great artist, congrats!
I've bought an XP-Pen Artist 22EPro, but I found myself struggling too much with the lack of configurable keys (even if this one has 16 of them). The vertical mouse is a standard one, I'm actually using it for when I'm not drawing and it's helping me a lot! The plan is to use my previous mouse only when I have to draw and animate, then I'm gonna switch to the vertical for anything else!
Wrist update: I'm almost ready to start drawing again! I've tried drawing a bit during the last days and my wrist is getting better and better, even if it still hurts after a while!