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Came here because of Olexa and immediately bought the game. I really enjoyed it so far. 

I just have the feeling that poison is a little too strong especially if can literally get a run which gives you no option to cleanse it...

Additionally it feels like that you just get a thousand monster thrown at you at some point just to make it harder. Would love to see a bit more variety there. 

sadly, yes you need to replace permanently statused heroes. That’s why you get more heroes than loot.