There is a color guide in Vuu's house (where you begin the game) that will help with the puzzles and how they work. You will be able to access that guide from anywhere in the next demo.
If you don't have a mouse, you can still use WASD to rotate the heart (or anything you grab in the overworld) and F to right click.
As for colorblindness, that's what the symbols are for. These were added after a few colorblind people asked me for it, and I haven't had any complaints about it since then ^^