Very unique game! Some of the bios and descriptions were pretty funny, I see a lot of potential there for a lot of good humor.
It can be hard to tell what directly counters what. In theory, the mind control description seems like it would just win any fight, since there seems to be no limitations on its "difficulty" to use. I think having more in-depth descriptions would help with understanding what something really does, and what is needed to counter it.
There is a lot of potential here for a full game like this. Having more complex mechanics eventually, maybe like multiple hero's to take out, or even getting 2 of a certain power with your villain's can make a combo.
The art is very nice! Reminds me of papers please. Audio is also good, but im not sure if it fits the theme / gameplay of the game so much.