I'm not sure I answered your question to be honest ahahah The difference between the RPGMakers folder is based on the software version (eg. MV, VX, XP)
If you are using unity, don't use these files cause they are suboptimal :)
Viewing post in Modern Interiors - RPG Tileset [16X16] comments
Folders are sorted based on your grid size (16x,32x,48)
If you are gonna use a 16x16 grid, these below are the files you need: "interiors_16x16" has all the sprites from the day 1, the "Theme_Sorter" folder has all the sprites from the day 1 but sorted by theme and the "Room_Builder_16x16" has all concerning walls, floors, steps etc.