Hi SpaceDiceMan!
Firefly was one of the inspirations when I wrote the game, so you will find elements that feel familiar.
Impulse Drive doesn't have any pre-written setting directly, but there are a few assumptions in the basic moves and archetypes moves which do say something about what the PCs can do and how their situation will respond to them.
If you used the Smuggler ship playbook and sat down with your group to set expectations, you could play a game that felt like firefly in a lot of ways while taking your own spin on it and ruling out some gear or character modifications that don't fit your setting.