Did you metasize without upgrading anything in the malignant menu? Here's how it works:
1.You produce malignance with the malignance lored
2.You spend the malignance in the malignant menu
3.You metalize by confirming that in the malignant menu, and you restart the game, only with the new upgrades you got previously from the mm carry over
The same goes with the tumor lored, only that you reset the mm upgrades too.
I already metalized once. I literally got on to the game and my progress was gone