Yes, of course. My main monitor is a 21:9 (so 3440x1440) while the other one is a regular full HD 1920x1080. I tried fullscreen mode on both but with the same issue. Now playing in window mode is more than enough ;-)
I didn't get any crashes on old version. All I can say is that I was in a middle of a fight against a demon faction. Hope this may give you a hint to hunt it down :-)