Users expect indie projects on Itch.io, games made by a single dev (or a small team) while they have a full time job. There’s all kinds of projects here. Although this is a personal opinion, I would say that users looking for indie games are for the most part looking for a unique experience, something creative and innovative, that would be too risky for a big company to implement. So make sure to let your creativity flow.
Steam is higher profile, with a higher bar of entry. That’s a platform AAA companies also use, so your game will sit next to other high profile games. It’s easy for a user to judge your project with AAA standards.