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I use GIMP, mostly.

I love that it's open source and free, but of course that comes with some drawbacks. I've learned to work around most of them now. I wish I had a better set-up for animating, although I probably couldn't make use of one very well if I did anyway.

I'm not really sure how to describe my style, but its 2D and I suppose it's quite messy and low-tech.  I have to work quite small because my laptop/GIMP can't handle big files, but I'm also not very careful and I don't use a restricted palette usually, so it doesn't look like pixel art although it's often small enough to see individual pixels.

I have tried sprite lamp for dynamic lighting, but I didn't like the look of it in my style. I probably need more practice with it.