Looks interesting to use, just wondering, any compatability with Unity?
Or would I have to save it as one big sprite and work from there?
There is no native support for Unity, but there is a very nice Tiled2Unity solution for converting Tiled maps to Unity meshes and game object instances. There is also Tiled4Unity, a variation that avoids the need for using an intermediate application. Check out this page for other potential options.