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If the save file is from 1.8 or 1.8.1, then yes :)

The game save was with a new game started (as of last night)....and, after application of the 1.8.1 Hotfix.  Laptop was shut-off overnight.  Loaded the saved file this AM and was able to play about 3 hours without issue making periodic "new saves".  Closed the game for a couple hours....then came back to the game, loaded the last (most recent saved file); and, within a couple minutes or the same MS error message received prior to the 1.8.1 update and the game closed to desktop.  I'd gladly send the "output.txt" file; but, don't see any method to attach to this email system.....and, the game crashes prior to my being able to utilize "bug icon" within the game.

Game was playing great all last evening and this morning....don't recall anything I was doing differently within the game prior to this problem now.

Appreciate any insight.

See my earlier post.....I may have identified the problem which might be my fault.   Am I supposed to play the game ONLY WHEN LOGGED INTO THE ITCH ONLINE APPLICATION?  If yes, then that's the issue.  When I returned to the game (prior to my recent email), I wasn't logged into the ITCH APP.   But, to send the email, I logged on.  After sending the email, I then hit the "Launch" icon (while online) and tried to load the same saved file that failed earlier (prompting my email).  The game has now been running OK for the last 45 minutes or so. 

Sorry if I didn't realize the requirement to be logged in online to properly play the game.

I honestly wasn't aware of such a requirement with the app. Good to know!