If you're on android you can use the app joiplay, it works for most or many VN's.
Viewing post in [Full]HeroicSphere-Episode1 : CyberWolf [Bara/Furry] comments
I use tyranobuilder and I'm pretty sure the issue come to the fact that itch.io is not opening the .exe file when clicking launch(because it needs manifest file to tell him what to launch, according to itch documentation.) I am pretty confused on what itch is even trying to open tho as it open a njws application. It's like Itch think it's a Html 5 browser build.
My programming skill is basically 0 so I have no idea how to make a simple manifest file. It seems like using Butler might help too.