OS X 10.11.4, MacBook Pro (Retina, 15-inch, Late 2013).
I thought I tried different resolutions and graphics qualities, but apparently not, because it seems to work when I change both. I'm playing the game in windowed mode, also. The game appears to not function at 1024x768 with fantastic graphics, but seems to work with 800x600 with simple graphics. At least I can play it now. Thanks! Maybe some of these details can lead to a patch if you're up for it.