It used to run but now it doesn't? That's quite strange. When did you last play? Have you tried launching directly and via the itch launcher? Is there a more detailed error message or other logs? You can email logs to wildermyth at gmail and I will take a look.
Okay, thanks! I'll see if I can locate more specific information and then email you all. If I recall correctly, the issue first started when I moved the game to a new folder, though it's been a few months (stopped playing the game and only recently came back to it). Moving the game back to its original location did not fix things. The issue crops up both when trying to launch directly and when using the itch launcher.