One thing you could explore in the Vampire route is what caused the collapse of Noctorna, probably something Samantha or the King did by wresting control from Amber, and no Mila present to help Amber. And you could explore if that contributed to the decline of Mor Town.
Also you could explore what happened to the members of Noctorna, did they get turned into monsters (Vampires, Lycans, etc)? Were they killed by humans? or did they live out their lives and die of old age?
Another thing is what happened to that Vampire (Half-vampire maybe?) who was stealing the Orbs and who stole the cross?