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It seems I've forgot some quotes in pre-inst-env.in on line 10.

Other than that, you'll also need the (sdl2 mixer) module, which in turn needs SDL2_mixer. Similarly (sdl2 ttf) needs SDL2_ttf. Not sure which Ubuntu packages this maps to, but make sure you have them.

Yep, I had installed libsdl2-mixer and libsdl2-image while troubleshooting. But, only after installing guile sdl!

I reconfigured and reinstalled guile-sdl and was off to the races!