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I don't have a solution, but I'm having the same problem, also on Mac. It moves slowly/jerkily when I try to look around on any graphics setting higher than "low," and no combinations I've tried actually give me the working computer screen. It'll even show me where the recycling bin and database are if I hover over them, but since nothing is visible on the screen, clicking on them does nothing for me. Did you ever find a fix?

No. :/ Had to abandon the game for now.