Bloodborne wasn't really an inspiration, as I've never played it, BUT the implied setting is certainly open enough that you can drop such things in - and the game is lethal enough that it might even be a good fit.
That fellow with the monster hand is a magi (one of the species of player characters). They can cast more magic rituals per day than other characters at the cost of such physical mutation (such mutations don't have a mechanical effect, but can impact the narrative and interactions with other people).