If you mean those alleged game downloads from those spam comments screaming "new update here!", then yeah, definitely, they'll be containing some kind of malware and should be considered dangerous.
If you mean the official, direct downloads of games like TM from their official itch.io page, then no, those aren't dangerous for Android. I mean, I obviously can't check out all the over 9000 other adult games on itch to make sure there are no foul apples out there, but normally those should be safer than downloads from virtually any other places, except maybe a developer's own patreon page.