Cool core concept, I like the mana/forging system and think it could go in a lot of different directions. A little confusing at the start, but once it gets going it's pretty addictive. I appreciate starting us out with a bunch of health potions so we were able to explore more of the game even if I was taking a lot of damage. Oh also the sound/animations made this really juicy!
One specific suggestion: you can only see what the different runes do when you click on them, but that information is most important when we're in the forging screen, so it would be good if the runes would show their stats as a hover-text while you have the forge menu open.