Interesting game.
I like how you converted the RTP to black and white, cool move; I also did that in one of my projects that I never publicized and think it works well with the vignette overlay.
Atmosphere is the game's strength and lends well to the F&H style intro and game setup in general.
Not criticize you too much for using custom art for the sprites, but they did seem to clash a little with the environments. I think employing the same tactic you used with the tilesets and making an existing sprite black and white would have looked more uniform.
I like the pop art style of the in-battle enemies and the backgrounds - nice work.
Intriguingly, I gained enough blood packs to boost my blood to the requisite 6 gallons and thought my task was then to return to the surface, sadly not - so I did not complete it yet.
I shall return later to complete the game after checking out some more submissions.
Good work on the game, I like it :)