Loved the game, very well done, I died a few times learning how to cook meat to survive and such. My 3rd playthrough I was able to make all the potions and activate all the totems but the first one, as it no longer gave me an option to hand it the red potion.
Sadly it looks like your restart doesn't properly track if I have turned in a potion, as I made a red potion in my second playthrough and was never able to give another one, It seems like you track if they have turned in a potion separately from the tracking of if a totem is activated. Your restart option correctly turns all totems off and wipes the inventory and board, but does not ever allow giving a potion to activate those you have already activated in a previous life.
Otherwise would have been a solid 5/5 game for something made in 48 hours.