I would add a "hold a key to move the selection faster across the keyboard" function at the start of the game when you type your name in
The dialogue is great, a lot of funny stuff, character names etc.
Art is really nice, I like how the background can get damaged in battle, the music is cool and fits the atmosphere (which is really well done as well)
I would add an interaction with a little dialogue when the player tries to go somewhere he can't YET. I would tend to dismiss a door that did nothing at all when I interacted with it earlier. I'm only talking about the gas shop door here.
The progression might be a little hard in some spots, like where I got stuck at the end, but that might just be because I went on the cockroach "side quest" too early instead of going where I was asked to.
The "Mexican horse" demon having his dong hanging between his legs on his sprite was on point for DD69
A lot of tasteful details! The krokodil guy, the janitor getting splattered when you beat him, the stuff you get from looting them...
Lovely polished game!