I like the premise of your game; it's one of the most unique ones I've seen. I didn't expect to be deciphering Yiddish pronunciations for this game jam, haha.
For me, the difficulty stems from the lack of a tutorial. For one, it's not immediately understood that the words are written backwards as opposed to English. I feel like that should be explained first. It's also hard to find some of the symbols because they are hidden behind the menus of other symbols. The button in the bottom-left which changes how the symbols look could be explained as well (I have no idea what it means, but it helped me figure out the words easier).
Your audience is mostly going to be people who don't understand Yiddish, so taking the perspective of one who knows nothing about it would be a good approach for accessibility.