Hey so I played a few times with clicking and few times where I enabled an auto-clicker (at 10 clicks per second) and personally I would say I enjoyed the auto-clicker experience more. Yes it's a bit easiER, but I definitely wouldn't call it easy, it really depended on the mutations (which I think is the mark of a good roguelike). When I got the fire and speed upgrades the build felt really powerful, but when I got a combo like ice and shield (with enemies getting a speed boost like fire) I was fighting for my life XD. Now the reason I liked the auto-click more is because in scenarios where I had an underpowered build, I was heavily reliant on the dodge mechanic and maneuvering. The clicking really started to wear me out to the point where I felt I couldn't focus on the movement as much, it was much nicer to just aim the mouse and focus on the enemies so I could try and dodge their attacks, it made the combat feel more engaging. Ultimately this is just my own experience though, if you're still on the fence you could always keep the clicking as the default and then add an option in the settings to turn hold-to-fire on or off