If you have time, I’d always welcome more feedback on mine: https://itch.io/jam/godot-wild-jam-94/rate/4697177
I love the pixel art and UI! The hand animation is really cool lol. I know the cards are premade assets, but you incorporated them well into the atmosphere of your game.
The gameplay is well-thought-out and unique: I've never thought of a roguelike card game with mutations! Really creative!
Bonus points for having a tutorial for your combat system. It was slightly wordy though; I believe it would benefit from incorporating a show-not-tell mentality, where the player is guided through the game in a more-so visual manner. Think of PowerPoint presentations. The good ones balance their information with visual aid which helps maintain their audience's attention.
And try to make the tutorial re-playable too; it's a lot of information to remember!
Other areas of the game could benefit from a tutorial too. The high-or-lows act as their own tutorial, so those are fine.