Its a really good game! The idea fits the theme amazingly and the low health music is great!
I think the game has some balancing issues, some of the modifiers basically do nothing when you have another (increase damage doesn't matter if I'm on one shot etc) and I never really felt challenged. The choices made in moment to moment gameplay is next to non-existent, it might have been cool to have the player not locked to the green zone, but the timer only progresses if you're in there?
I did also run into a couple of problems, I didn't notice any change after selecting boomerang bullets? Also had a minute or so lag spike on level 29, after which I was just dead.
Overall I think that the idea is there and the choice of debuffs is engaging, but the active gameplay could do with some more work.