Learned all of those, game still got ridiculously unbalanced during the later areas because of the debuffs
What debuffs? Curses or passives that come from corruption? Most of curses could be avoided, and corruption... Serious stuff usually not earlier than second Mind Room.
It's good that you knoew all mentioned mechanics, it's a basis for this game. Could you describe more what is the main problem in your walkthrough?