for #2, you can spend 1 blue wisp while in the latex puddles to effectively reset the 'countdown'
(similar to how you can use some when captured by, say, a mimic or fox guard)
Though to actually remove the debuff you need to get through all the floors (think it was 11) and 'end' the demo. Which... is somewhat RNG dependant but not too bad if you're cautious and/or have a good stock of blue whispsPersonally I usually get that effect sooner or later, but that's another matter.