Nice update. Some comments:
Only the enemies in the first act have a ‘defeat route’ option. Is this intentional or have later ones just not been added?
Vinetrap is insanely annoying. Feels like the sort of cripple an elite would use, not a basic mob.
The Collector is unfair. Not because it is hard, bosses are supposed to be hard, but because unless you kill it turn one with an infinite cheese deck it cripples you for the following floors because all your items are unequipped. You might win the fight but it near guarantees you loose the run.
Resin + Thorns is by far the most powerful build. It isn’t powerful enough to actually win in most cases but it looses later than other builds.
Possible bug: Items with ‘When first equipped gain max health” do not increase max health, but do heal you.