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Thanks for a very nice comment! :D

1. That's true, so that's why I try to rely a bit more on realistic references, and translate them into pixelart, rather than making pixelart animations from scratch. Although I have found a relatively good solution to this mouth movement sync. You can see in the "Empty Party" game. 

2. Thanks a lot letting me know that I can quote you that it is a bit harder than usual ;)

3. Interesting. I can vaguely remember that some old games had some mouth lip sync, which was sometimes hilarious to watch. As a grown-up, I truly understand that it was very hard to do with the older programming languages like Assembly and C, and audio formats of lower quality. I recently played some scenes of Gabriel Knight (original game), and it seems the lip sync is great, but I don't know if it is synced perfectly with the oral pronunciation of words and sentences which often differs from written language. 

4. Coming back to point 1, I think I must make three-fold arrays of sentences, one describing ASL sentences which differs from written grammar, one describing written grammar, and the third showing correct pronunciation with which lip movements sync. The first two players can see in textbox, and the third one is hidden for players, but it is shown in the protagonist's mouth movements.