here's a suggestion list of stuff that's been rattling in my head. you can do all of or none of these ideas.
mood - not sure how it would work mechanically but sounds like something that could work.
sleep disruption - sometimes you're forced to wake up in the middle of the night.
rent - I've noticed how easily you can accumulate money, this would be a good way to limit that (could be every 20 days or something)
food variety - could just be completely cosmetic, let the player eat more than just burgers lol.
Lactation (cause my brain wouldn't let it go) - doesn't have to be tied to an new animation or picture, implied text is good enough. you could store milk in a bottle (perhaps you can save it to improve mood or sell it to help with rent or something). could be linked to breast size (like at size 1 you can make 1 bottle every 5 days and at size 2 you can make 2 bottles).