Edit: found the issue, holding shift was intended to block interact input until release but the callback wasn't being affected as expected (super quick fix but obviously nothing can be done for the jam). My testers were generally pretty light on the inspects so none of us caught it. Sorry about that!
Is it a text box like the inspect box (transparent rectangle in the middle)?
There is an occasional bug in 2D space where interactions get messed up and the level needs to be restarted (part of why fast travel is always unrestricted), my current theory is that it's a proximity edge case putting things in a funny state. I haven't been able to hit it myself yet, but my main tester has seen it a couple times and they tend to move the character around more actively than I do. A UI element being stuck on the screen is interesting though, my tester mostly just got teleported in the rare case where they ran into issues.