I have the same feeling about that boss. It’s possible to find specific relics to work around it, but in the absence of those relics, it seems far too punishing.
Note, for instance, that Balatro has bosses like “don’t use the same hand twice” or “only use one hand type” or “all face cards are debuffed”, which can punish certain types of builds, but it doesn’t have anything like “all enhanced cards are debuffed” or “cards can’t give you mult”.