I like when I understand an idea and how to play it. There are still some improvements in clarity, but after getting the hang of it, I played a bit. I still didnt understand what the sliders and the buttons did fully, but focusing on the timeline and discovering combinations was actually fun.
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The sliders are placebos for micro management!
lol, no seriously, I struggle to feel they have any effect. The formula is that the slider value (going from 0 to whatever is displayed at the top) is divided by 100.0, and added to the weight of that drug, or addict, appearing, which are typically, but not necessarily rated at 0-1.0 by default (it varies). All weights are relative, so you have to know the weights for all the other items, which vary as the game progresses. So I absolutely sympathise with any confusion.
Being part puzzle game, I wanted to let the player figure stuff out. Being part simulation, there are parts that are modelled by complicated equations.
Hope this sheds some light. Thanks for playing.