Skip to main content

Indie game storeFree gamesFun gamesHorror games
Game developmentAssetsComics
SalesBundles
Jobs
TagsGame Engines

That error ("Failed to initialize a .NET domain") usually means something is preventing MelonLoader from initializing properly.

Since the issue persists after following the guide, you can try the following:

  • Make sure you are using a compatible MelonLoader version (for 0.95.16, versions like 0.7.2 or specific 0.7.3 nightly builds are recommended)
  • Completely remove MelonLoader and reinstall it cleanly
  • Delete any leftover MelonLoader files/folders before reinstalling (such as MelonLoader, Mods, UserData, etc.)
  • Ensure you are installing it into the correct game directory
  • Temporarily disable antivirus or add the game folder as an exception
  • Make sure your system has the required .NET runtime installed (latest supported version)

If you are not on Windows (for example Linux or Mac), this error can also happen due to lack of native support.

If the issue still continues, please provide:

  • Your game version
  • Your MelonLoader version
  • Your operating system