I fixed the crash with building factories and hopefully it affects other issues as well? Please try it out. Version 0.9.5 is now available for Windows. Mac build coming later today.
Mine always crashes after about 15 minutes as well. Still crashing even with the most recent update. No matter what save game it is either.
Windows 10, 64 bit
6 gigs of ram
intel i5 6200U
GPU is intel integrated 550m I believe.