Ren'Py is a very poor engine for creating games accessible via screen readers. Therefore, to fully support these devices, we need to add a lot of custom features, which is currently problematic.
If you or your friends use such devices, we can currently only provide information about the plot and other things that can be conveyed in text form outside of the game. We also recommend discussing the game on Discord, as itch is not well suited for these types of things.