Congrats on making a submission, even if it is just an initial prototype.
I struggled to play the game using VoiceOver on Mac OS X - often the screen reader would lose focus on the game, and moving and interacting with different elements didn't give enough affordance or details on what I was focusing on. Some additional details about what the content on the screen is would help a lot here too. If you end up doing more testing and getting it working with VoiceOver, I'd love to give it another try!