If you’re making management / spreadsheet style sims, you don’t really need a heavy game engine unless you want more visual polish later.
If you want to stay in Python, I’d look at DearPyGui or Kivy instead of PySide — they’re much nicer for building lots of menus, tables, and panels quickly.
Godot is actually a good fit for this genre because its UI system is strong, but yeah, it feels overwhelming at first. You can ignore most engine features and just treat it as a UI layer for your sim logic.
Another solid option is a web-based UI (HTML/CSS/JS) with Python as the backend (Electron or similar). That works really well for data-heavy games and gives you great tools for tables and layouts.