I was playing on Windows 10 Pro version 21H2, 16GB of RAM. When I started a fight, it crashed in any mode.
Let me know if you have any success trying what I suggested. You can also switch to using the Retro pixel art mode together with the rest or on its own, just to see if there is any option that doesn't lag/crash. Also try to use FSR, either Quality or Ultra quality (or any other options, to see if they help)