So Alt+Enter doesn't fix the issue? I did see something a couple of times where the shaders wouldn't compile the first run of the game. Restarting seemed to fix it. What sort of video card do you have? Maybe there's something in there to try configuring. Like reset to default anti-aliasing and other features (set to "Let App Decide"). Maybe open up Task Manager (Alt+Shift+Escape) and see how your performance is.
There are some additional command line options here https://docs.unity3d.com/Manual/CommandLineArguments.html and scroll down to "Standalone Player". Maybe try "-force-glcore"?
Just some ideas, sorry I can't be more helpful.