Thanks for the video!
Your PC definitely hates running the game for some reason. I've not seen anyone with PC specs as good as yours struggle, which is a bit strange. I'll be honest, it's not the best optimised game (and Game Maker isn't designed for such large rooms) but any modern dedicated GPU should handle it. Perhaps your configuration is a rare exception.
A few general things to try:
-Try turning V-Sync off in the game settings. Also try running with Frame Skip turned on. Make sure anti-aliasing is turned off.
-Check the Windows task manager while the game is running. Is the CPU or GPU at 100% by the game? If the usage is still low, you should be able to increase the priority given to the game.
-I believe NVIDIA GPU's have a software controlled option to clear the cache. This may help, I don't have an NVIDIA card so I can't testify.
-Check all video drivers are up to date.
-Decreasing the resolution of your main display may improve performance. To be fair, Total Anarchy doesn't look much different in 720p than it does in 1080p.
Hope this helps :)